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CBD Oil Side Effects

CBD, which is short for cannabidiol, is most commonly produced as CBD Oil and made by mixing the CBD oil extract from the cannabis sativa plant with an inert carrier oil such as hemp oil. It is widely touted as having numerous therapeutic benefits for the body and mind from improving sleep, minimising the effects of chronic pain and helping to alleviate anxiety. Whilst CBD Oil Benefits are greatly welcomed, it must be acknowledged that they come with a set of potential side effects. Appropriate dosing will typically mitigate these side effects but we shall proceed with looking into what might be experienced


Side Effects

There have been a number of different side effects associated with CBD oil use. The most common tend to be dry mouth, light headedness, low blood pressure and drowsiness. These side effects tend to be mild but any discomfort should naturally be accompanied with a lower dose or discontinuation. Women who are breastfeeding or are pregnant are advised to avoid using CBD oil as a precaution against any contaminants that might be present in the products. Whilst their presence is severely unlikely, it is best not to risk any harm to the infant or unborn child.

Other side effects that you might need to be cautious of whilst using CBD oil are anxiety, changes in appetite, changes in mood, diarrhoea, dizziness, nausea or vomiting. Everyone will have a different experience when using CBD oil and so monitoring any changes to your body’s function is an important part of the process.

There have also been some reported concerns for people with eye issues. A study from 2018 found that people suffering with glaucoma could have an adverse reaction to CBD oil, resulting in an increase in pressure inside the eye. Some participants also reported having an increase in the dryness of their eyes which was a source of discomfort.

CBD oil can also have an impact on how other medications interact with the body. CBD can impact on the function of the enzyme cytochrome P450, which is produced in the liver. Cytochrome P450 is responsible for breaking down specific drugs into smaller quantities so they can be more readily absorbed by cells. As CBD can inhibit the function of cytochrome P450, the efficacy of other pharmaceuticals can be impacted. It is advisable not to combine CBD with other drugs for this reason although we also suggest seeking advice from your medical professional about such outcomes.


Rare Occurrences

In rare circumstances, which are related to an extremely high dose, liver function can be severely impaired by CBD oil use. A study in mice found that very high doses caused heightened liver toxicity, with swelling and inflammation prevalent. Whilst it might provide reason to exercise caution around CBD use, it must be noted that the experiment administered a dose of up to ten times more than would be recommended for a human to take. It is very unlikely that such prominent side effects would be experienced if dosing was made appropriately.

Given these occurrences, albeit they happen infrequently, if you are suffering with liver disease or abnormal liver function, caution should be taken with any CBD oil usage. It should also be noted that CBD oil has helped play a part in regulating a healthy liver function, by helping to regulate endocannabinoid production which is responsible for helping the body achieve homeostasis. It has also been found to assist people with liver cancer, deterring the spread of tumour cells and helping to preserve healthy cells.


There are a number of side effects to watch out for when using CBD oil. They can be properly monitored by regulating your dose and keeping it at appropriate levels. Whilst in extreme circumstances, it can negatively impact liver function, it is also found to be useful in helping people with healthy livers and provide desirable outcomes in people with liver cancer. Moderation is key!

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